Substance produces wines from Columbia Valley, Washington's premier growing region. The winery's portfolio centers on Merlot and Bordeaux blends sourced from distinguished vineyard sites. The Bordeaux Blend Klein Vineyard, built from Cabernet Franc, Merlot, and Cabernet Sauvignon, represents the winery's approach to structured, age-worthy reds. Merlot forms the backbone of the range, with bottlings from Stoneridge and Northridge vineyards showcasing the variety's depth in this terroir. Columbia Valley's warm days and cool nights create conditions for ripe fruit and balanced acidity—hallmarks of the region's best work. Substance's wines have been assessed by Wine Enthusiast, Wine Advocate, Decanter, Wine Spectator, and Falstaff.