Casa Grande Sant'Ana sits in Minho, the northernmost wine region of Portugal and heart of Vinho Verde. The winery works with the native varieties that define the region's character: Arinto de Bucelas, Loureiro, Trajadura, and Avesso. These grapes thrive in Minho's Atlantic-influenced climate, yielding wines marked by brightness, minerality, and the gentle fizz that Vinho Verde is known for. The Vinha da Cruz Branco leads the portfolio, a white of considerable depth for the region. Escolha, a blend of three regional varieties, and the single-varietal Avesso round out the core offerings. Wine Advocate has rated across the range, recognizing the technical precision in the winery's approach to these delicate, food-friendly expressions.