Santa Tresa produces wines from Sicilia, in southern Italy's Terre Siciliane region. The winery works with indigenous Sicilian varieties: Orisi, Nero d'Avola, and Inzolia. Its flagship red, Orisi Rosso, draws from the rare Orisi grape native to the island. Avulisi Riserva, made from Nero d'Avola—Sicily's signature dark variety—represents the winery's commitment to regional expression. Insieme Orange, an orange wine crafted from Inzolia, reflects the winery's willingness to explore unconventional techniques with white grapes. These wines have been assessed by Wine Spectator, Wine Enthusiast, and Decanter.