Poliziano produces wines from central Tuscany, drawing on the region's traditional varieties and modern blending approaches. The winery's Vin Santo di Montepulciano—a blend of Grechetto and Malvasia—represents the fortified style for which Montepulciano is known, balancing oxidative aging with aromatic complexity. Ambrae del Poliziano pairs Chardonnay with Roussanne to create a white of structure and depth. The Mandrone di Lohsa Maremma Toscana Rosso blends Sangiovese with Alicante Bouschet, Petit Verdot, and Cabernet Sauvignon, layering the region's signature red grape with international varieties for added texture and weight. Wines from Poliziano have been assessed by Wine Spectator, Wine Advocate, Wine Enthusiast, Decanter, and Falstaff.